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Research Associate II-Vivarium

  • Location: Petaluma
  • Salary: US$76000.00 - US$114000.00 per annum per year
  • Job Type:Permanent

Posted 17 days ago

  • Sector: Life Sciences
  • Contact: Shannon Griffin
  • Expiry Date: 12 April 2023
  • Job Ref: JN -022023-477072

We are seeking a motivated Research Associate 1 (RA1) or RA2 (depends on experience) to join the company's Animal Resources (Vivarium) Group to assist in managing administrative functions and rodent model use in the animal program. This position is critical to regulatory compliance for the company's Animal Care and Use Program.

The successful candidate will have a dynamic role in managing

breeding colonies at contract research organizations (CRO's) and within the

company's in-house vivarium. This will include coordinating genotyping

sampling and data and ensuring the multiple Therapeutic Area groups attain the

appropriate rodent models needed for studies. The successful candidate may

also assist in the development, optimization, and implementation of genetic

rodent models of multiple rare diseases. In addition, the successful candidate will

manage procurement of animal subjects for in-house experimental use and may

also assist in in-vivo study activities for various therapeutic indications,

including dosing of test article in rodents, tissue collection, and sample




Organize and maintain genetically engineered rodent colonies.


Engage with project teams and Therapeutic Area (TA) scientists

in a collaborative manner to ensure efficiency in cohort planning.


Coordinate procurement of animal subjects from vendors and

CRO's. Track inventories and costs associated with animal procurement.


Recognize, understand, and adhere to IACUC approved protocols,

policies, and procedures.


Manage genotyping sample processing.


Perform in vivo lab procedures including but not limited to

rodent dosing (ip, iv, sc, im, etc.) studies, breeding setups and husbandry,

genotyping sample collection, blood/tissue collections.


Share responsibility for lab maintenance duties.


· Bachelor's degree and at least 4 years of experience; Master's degree with at least 2 years of relevant experience

· Extensive in-vivo experience and familiarity with genetically engineered mutant rodent models, including mouse of disease models

· Experience in breeding colony management and familiarity with mouse model creation processes and techniques (e.g. CRISPR, Cre-lox and Tet-on systems, mouse IVF concepts) and familiarity with mutant model types (transgenic, knockout and knock-in models, conditional and traditional mutant lines) is highly desired

· Proficiency in in-vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is preferred

· Familiarity with Animal Care and Use Laws and Regulations is highly desired as this position will be required to manage animal use inventories/census against Animal Care and Use Protocols (ACUPs)

· AALAS certification at the LAT/LATG level highly desirable

This position is full-time on-site and based in Petaluma,