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Scientist, Chemistry

  • Location: South San Francisco
  • Salary: Negotiable per year
  • Job Type:Permanent

Posted about 1 month ago

  • Sector: Careers at Hydrogen
  • Contact: Summer Martinez
  • Expiry Date: 02 October 2022
  • Job Ref: JN -082022-473435

Scientist, Chemistry

We are looking for an energetic and talented Scientist to join the medicinal chemistry group reporting into the Director, Chemistry. The successful individual will help to drive preclinical advancement of our drug portfolios within the chemistry group.

Responsibilities

  • Synthesize novel small-molecule anti-cancer drugs, linkers, and linker-payloads with functionalities suitable for covalent site-specific conjugation to proteins
  • Working within the team to help identify the most promising candidate linker payloads while taking the steps required to progress these toward pre-clinical evaluations
  • Execute procedures from standard ACS-style experimental descriptions and work independently, while still receiving direction and support from your supervisor and teammates
  • Engage in cross functional teamwork, including computational-, analytical- and biochemical chemists, to execute research projects
  • Apply modern techniques of solution- and solid-phase organic synthesis including a variety of organic reactions at several scales, microwave chemistry, inert atmosphere techniques
  • Participate in general laboratory and chemistry responsibilities, compound registration and small molecule (reagent) cataloging
  • Contribute to patent application writing and research reports
  • Maintain an easily comprehended laboratory notebook and a record of the chemical analyses of all synthetic compounds, both intermediates and final products

Qualifications

  • Ph.D. in organic chemistry with strong emphasis on multistep organic synthesis, preferably with total synthesis background
  • Experience in modern synthetic organic chemistry techniques, designing new synthetic routes for biologically active molecules and carrying out multi-step synthesis in milligram to multi-gram scale
  • Hands-on experience with purification techniques (normal and reverse phase chromatography, crystallization)
  • Hands-on experience with analytical and purification instruments (HPLC, LC-MS, flash chromatography and NMR, etc.)
  • Good lab notebook and writing skills
  • Familiarity with chemistry software such as SciFinder
  • Good problem-solving skills and a strong sense of teamwork
  • Excellent oral and written communication skills are essential



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