On-site position in San Rafael, CA
Relocation support provided
Salary Range: $116,000 - $168,000
The company's Musculoskeletal Therapeutic Area is seeking a highly motivated Scientist I or II to join the team.
The successful candidate will be responsible for the intellectual and hands on evaluation of therapeutic strategies in support of the research pipeline. In the act of doing so, they will have multidisciplinary interactions with dozens of colleagues throughout Research and across the business. This is primarily a laboratory-based role where in vitro molecular, cellular, genetic and biochemical methods will be applied.
The successful candidate has:
- A passion for finding treatments for rare genetic diseases.
- A strong foundation in molecular, cellular, genetic, and biochemical concepts and methodology as demonstrated through publications and presentations.
- Designing and carrying out lean sets of experiments that produce actionable data; proposing hypotheses, testing them, and delivering reliable results consistently.
- Rapidly mastering new fields and methods and connecting with KOLs.
- Presenting experimental results, conclusions, implications, and next steps.
- Meticulously adhering to electronic data recording standards.
- Incorporating guidance into project strategies.
An expert level ability to develop & conduct the following methods, and to analyze, present, and quickly iterate upon the data generated:
- Protein quantification: ELISA, Western/WES or other, and a conceptual understanding of LCMS.
- mRNA/DNA quantification: qPCR, ddPCR, knowledgeable of NGS approaches, prep and analysis.
- Microscopy: Confocal or other with a breadth of knowledge in sample preparation and image analysis to visualize and quantify cellular events.
- Deep experience in cell culture approaches: Knowledgeable on cell lines to use for various applications and Flow cytometry or FACS; has applied transfection and transduction approaches, gene editing, and generated edited or transgenic cell lines.
- Modern and traditional molecular cloning approaches (Gibson, etc).