We are looking for a talented and experienced individual to join a growing biotechnology client as a Lead Formulation Scientist. The Lead Formulation Scientist will be responsible for understanding the small molecule chemistry, degradation pathways, characterization, and stabilization techniques. The selected candidate will be designing and screening formulations for optimizing solubility and stability of drug candidates for ophthalmic and injectable drug products. This is a full-time opportunity, and will be based in San Diego, CA.
· Exhibit strong scientific acumen, with ability to solve problems of medium/high complexity via independent planning, design, execution, and interpretation of experiments.
· Design and develop robust, scalable formulations, manufacture prototype dosage forms, and conduct drug product process development and process optimization activities in-house.
· Design and conduct pre-formulation, formulation development, process development and process optimization of parenteral and ophthalmic formulations and related alternate drug delivery systems such as solutions, lyophilized products, sterile injectable suspensions etc.
- Perform development and validation of methods for drug products, and prototype formulations
- Experience with sample prep and method development for analytical testing including experience with HPLC-UV, LC-MS.
- Design and conduct experiments to characterize ophthalmic formulations, drug delivery systems, and drug-eluting formulations, including but not limited to release profile, solubility, loading capacity, degradation, and stability.
Key Qualifications & Competencies
· BS in Chemistry or related technical field; MS and/or PhD preferred but not required.
· Minimum 7+ years' experience in early-stage formulation development of small molecules.
· Experience in performing early phase formulation/process development of sterile dosage forms for small molecules. Hands-on experience in solubilization and stabilization of small molecules as well as understanding of mechanisms of degradation and stabilization of molecules.
Please apply with your most up to date resume to be considered.