(Senior) Formulation Scientist Product Design
We are looking for someone who has:
·A Ph.D. in Pharmacy/Pharmaceutical Sciences, Chemistry, biochemistry, biomedical engineering o[GN1] r related fields with 0-2 years[GN2] of post-graduate laboratory experience in nanoparticle formulation development, nucleic acid therapeutics, or drug delivery. Industrial experience in formulation development and scale-up manufacturing of nanoparticle-based modalities is an asset.
·Knowledge of nano-sized pharmaceutical formulations, and requirements for their parenteral and local application. Knowledge of standard methods for LNP preparation and characterization is highly desirable.
·Expertise in physicochemical or structural characterization of lipid and polymer-based nanoparticle preparations (e.g. DLS, gel electrophoresis, HPLC). Insights into advanced characterization techniques such as Cryo-TEM, SAXS, CD, AF4 is a plus.
·Experience in providing formulation expertise and insights to interdisciplinary teams during preclinical development. Hands on experience in conducting cell-based assays as well as in vivo PK/PD and efficacy studies for formulation screening is a plus.
·Cultivate a scientific mind-set, dedicated commitment, flexibility, creativity and team spirit.
·Fluency in oral and written English is essential with the ability to work with state-of the art software tools.
As Formulation Scientist your responsibilities include, but are not limited to:
· Independently design, develop and organize scientific experiments in the area of innovative mRNA delivery systems and optimization of existing drug delivery formulations (e.g. interpret results, evaluate data, write and review reports).
Contribution to develop and implement new technologies or strategies within the team to solve drug delivery challenges (e.g. communicate/interpret and present results, evaluate data, write and review reports).
·Analytical characterization and optimization studies (excipient screening, stability, and shelf-life determination)
·Supporting transfer and scale-up of manufacturing processes to GMP production
·Design of animal studies for PK/PD, efficacy and safety assessment of novel formulations
·Communicate and interact with different departments across the corporate, external project partners and clients to facilitate transfer of knowledge.
·Technology scouting and evaluation, patent and literature search as well as scientific and business writing.