Title: Oligonucleotide / Peptide Purification Development
Location:
Cambridge, MA
Pay:$48.00-$55.00/hr
Schedule:
Standard Office Hours
Duration:
6-Month Initial Contract
We are seeking a highly motivated and creative scientist or engineer with process development experience to join an Oligonucleotide / Peptide Purification Development team. This position offers the opportunity to develop robust, high-purity purification processes for oligonucleotide and peptide therapeutics and gain hands-on exposure to the design, development, scale-up, and transfer of manufacturing processes supporting clinical and commercial programs.
The successful candidate will contribute to the development of novel purification technologies and processes, working across laboratory, pilot-scale, and manufacturing environments.
Key Responsibilities
- Develop and characterize purification processes for oligonucleotide and peptide therapeutics, including process development, process characterization, robustness studies, and scale-up.
- Support purification unit operations including chromatography, detritylation, and ultrafiltration/diafiltration (UF/DF).
- Utilize multiple chromatography modes and support or learn additional processing steps including chemical cleavage, conjugation, and hybridization.
- Investigate novel purification technologies and approaches designed to improve purity, process robustness, and productivity.
- Support early- and late-stage process characterization and robustness studies.
- Scale up and transfer oligonucleotide purification processes into pilot-scale and GMP manufacturing facilities.
- Contribute to technology transfer activities, manufacturing documentation review, troubleshooting, and on-the-manufacturing-floor support.
- Support root cause investigations and process evaluations, working independently where appropriate with guidance from the supervisor.
- Collaborate cross-functionally with teams supporting synthesis, drug product, analytical development, research, manufacturing, project management, and technology transfer.
- Document laboratory and development activities through development reports and other technical documentation.
- Lead or support pilot-scale activities and small, focused technical initiatives.
- Provide training and mentoring to new employees as appropriate.
- Participate in the preparation and authoring of CMC/regulatory sections for IND submissions.
Qualifications
- Demonstrated experience successfully planning and executing scientific projects and experiments.
- Hands-on laboratory experience with the purification of proteins, peptides, and/or DNA/RNA.
- Experience using column chromatography, such as:
- Ion exchange chromatography
- Hydrophobic interaction chromatography
- Reversed-phase chromatography
- Experience with ultrafiltration/diafiltration (UF/DF).
- Hands-on experience analyzing proteins, peptides, and/or DNA/RNA, preferably using HPLC and UV/Vis spectroscopy.
- Demonstrated technical proficiency and creativity in developing or evaluating purification technologies and approaches.
- Strong organizational, written, and verbal communication skills.
- Ability to work effectively both independently and within cross-functional teams.
Preferred Qualifications
- Experience with ÄKTA purification systems and UNICORN software.
- Experience with Design of Experiments (DoE).
- Experience with statistical analysis.
- Experience with process scale-up, technology transfer, or GMP manufacturing environments is beneficial.
Education & Experience
Associate Scientist 3 / Engineer 2
- Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or a related life science field with 2–4 years of industry experience; or
- Master’s degree in a related field with 0–2 years of industry experience.
Senior Associate Scientist
- Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or a related life science field with 4+ years of industry experience; or
- Master’s degree in a related field with 2+ years of industry experience.
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